PHARMACOKINETICS OF GALANTHAMINE (A LONG-ACTING ANTICHOLINESTERASE DRUG) IN ANAESTHETIZED PATIENTS

High-performance liquid chromatographic determination of galanthamine, a long-acting anticholinesterase drug, in serum, urine and bile.

The anticholinesterase drug galanthamine is obtained from alkalinized serum by repeated liquid--liquid extraction. The resulting extract is approximately 100 times concentrated with respect to the original sample. Quantitative determination of galanthamine is performed with normal-phase liquid chromatography using a mixture of dichloromethane--n-hexane and ethanolamine as an eluent. Phenacetin ...

Pharmacokinetics of Long-acting Tenofovir

Long-Acting Oxytetracycline–Polyethylene Glycol in Horses: Pharmacokinetics and Tolerance

A long-acting oxytetracycline in polyethylene glycol (PEG) was evaluated in a single dose study at 6.6 mg/kg IV and IM and in a long-term dose study at 20 mg/kg IM q 72 h. Pharmacokinetic results were typical for long-acting oxytetracycline formulation. The intramuscular injections caused local irritation, but oxytetracycline-PEG did not alter microbial flora or cause adverse gastrointestinal e...

Pharmacokinetics of olanzapine long-acting injection: the clinical perspective

Olanzapine long-acting injection (OLAI) is a sustained-release depot antipsychotic for the treatment of schizophrenia in adults. Our objective was to explain the pharmacokinetics of OLAI to provide clinical insight. Simulation models and data from clinical trials are presented. Olanzapine concentrations were observed immediately upon injection. Half-life was ∼30 days, controlled by the slow rat...

TREATMENT OF PRECOCIOUS PUBERTY BY A LONG-ACTING GONADOTROPIN-RELEASING HORMONE ANALOGUE IN CHILDREN

The GnRH analogue has been shown to be effective in the treatment of precocious puberty when given as a daily subcutaneous injection. We studied the effectiveness of a long-acting GnRH analogue, Triptoreline, for the treatment of central precocity, by suppressing gonadotropin and estradiol secretion in three children with true precocious puberty. One month after single dose intramuscular i...